The main difference between neurons and glial cells is that the neurons are the structural and functional units of the nervous system, whereas the glial cells are the non-neuronal cells of the nervous system.
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When a nerve impulse (which is how neurons communicate with one another) is sent out from a cell body, the sodium channels in the cell membrane open and the positive sodium cells surge into the cell. Once the cell reaches a certain threshold, an action potential will fire, sending the electrical signal down the axon.
The nerve cell releases chemical signals, called neurotransmitters, which travel across the synapse to another neuron to create a new electrical wave in that cell. Figure 1 ” The structure and function of a nerve cell (a “neuron”).
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So one neuron, the transmitter, uses a really thin strand called an axon. A second neuron, the receiver, can receive contacts along its main body, or along strands that branch out like a tree, called dendrites. When the axon tip of a transmitter connects to a receiver, that’s a synapse. Neurons run on electricity.
Neuroglia are a large class of neural cells of ectodermal (astroglia, oligodendroglia, and peripheral glial cells) and mesodermal (microglia) origin. Neuroglial cells provide homeostatic support, protection, and defense to the nervous tissue.
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A nerve cell (neuron) consists of a large cell body and nerve fibers”one elongated extension (axon) for sending impulses and usually many branches (dendrites) for receiving impulses. The impulses from the axon cross a synapse (the junction between two nerve cells) to the dendrite of another cell.
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When a neuron spikes it releases a neurotransmitter, a chemical that travels a tiny distance across a synapse before reaching other neurons (Fig 1). Any time a neuron spikes, neurotransmitters are released from hundreds of its synapses, resulting in communication with hundreds of other neurons.
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For example, skin cells can only make skin cells, and nerve cells can only make nerve cells. Which statement best explains why skin cells can never become nerve cells? A- Each type of cell gets a different message from the central DNA, which is stored in DNA cells.
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Both cells arise from the same type of embryonic layer, the ectoderm. Both also have the same basic organelles when they are formed, including the nucleus, which contains genetic material, and the mitochondria, which produces energy, though skin cells eventually lose their organelles.
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We learned in biology class that every cell in the body has the same DNA. Whether a heart cell, skin cell or muscle cell”they all read from the same genetic blueprint.
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The length of a nerve cell can vary from nanometers to meters . Yes, it’s true. Our body is composed of millions to billions of nerve cells. Some nerve cells can be comparatively smaller by 0.1 millimeter or can be longer by 1 meter.
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The largest part of the brain, the cerebrum initiates and coordinates movement and regulates temperature. Other areas of the cerebrum enable speech, judgment, thinking and reasoning, problem-solving, emotions and learning. Other functions relate to vision, hearing, touch and other senses.
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Neurons aren’t properly connected. They signal to one another ” the electrical output of one neuron influences the activity of the neurons to which it is supposed to be connected. But there are tiny gaps between the output of one neuron (the end of its ‘axon’) and the input of the next neuron (its ‘dendrites’).
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The nucleus is like the remote control center of the cell. It acts as the cell’s brain by telling it what to do, how to grow, and when to reproduce. The nucleus is home to the cell’s genes.
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The brain can produce new cells Neurogenesis is now accepted to be a process that occurs normally in the healthy adult brain, particularly in the hippocampus, which is important for a learning and spatial memory.
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The major function of nerve cells is to transfer messages in the form of electrical impulses to different parts of the body. Nerve cells are long and have branches because they need more surface area to pass the signals to cell by cell.
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The Makings of a Genius Keeping in mind that his is just one brain, with regard to size, the assumption that “bigger is better” was found to be false. Additionally, from studying his brain, the assumption that more cells makes for a better brain was also put to rest.
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Neurotransmitters are synthesized in the cell body and are transported to the terminal synaptic buttons of the axon where they are encapsulated into vesicles and stay close to the synaptic region of the button.
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As a rule, the synthesis of small-molecule neurotransmitters occurs within presynaptic terminals (Figure 6.6B). The enzymes needed for transmitter synthesis are synthesized in the neuronal cell body and transported to the nerve terminal cytoplasm at 0.5″5 millimeters a day by a mechanism called slow axonal transport.
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Neurotransmitters are synthesized by neurons and are stored in vesicles, which typically are located in the axon’s terminal end, also known as the presynaptic terminal. The presynaptic terminal is separated from the neuron or muscle or gland cell onto which it impinges by a gap called the synaptic cleft.
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Neurotransmitters are generally synthesized in neurons and are made up of, or derived from, precursor molecules that are found abundantly in the cell. Classes of neurotransmitters include amino acids, monoamines, and peptides. Monoamines are synthesized by altering a single amino acid.
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Not all of the neurotransmitters that you have heard about may actually meet every one of these criteria. The chemical must be produced within a neuron. The chemical must be found within a neuron. When a neuron is stimulated (depolarized), a neuron must release the chemical.
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The precursor needed for the synthesis of small molecule neurotransmitters is taken up via transporter proteins located in the plasma membrane of the nerve terminal, and the neurotransmitter is synthesized in the presynaptic nerve terminal from the precursor.
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Dopamine constitutes about 80% of the catecholamine content in the brain. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical, L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals.
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Biosynthesis of all monoamines occurs primarily in the nerve terminal. As shown in Figure 12.7, the first step in the synthesis of catecholamines (DA and NE, as well as E, not shown) is the hydroxylation of the tyrosine to form DOPA.
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Acetylcholine is a non-monoamine neurotransmitter that is prevalent in the central and peripheral nervous systems.
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The neurotransmitter diffuses across the synaptic cleft and binds to receptors on the postsynaptic membrane. Depending on the specific neurotransmitter and postsynaptic receptor, this action can cause positive (excitatory postsynaptic potential) or negative (inhibitory postsynaptic potential) ions to enter the cell.
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In striking contrast, neuropeptides are initially synthesized in the cell soma, sequestered within the lumen of the secretory pathway and transported down the axon while undergoing cleavages and other processing events, after which the peptide-containing, large dense core vesicle (LDCV) is used once.
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Neurotransmitter precursors are nutritional supplements such as vitamins, minerals and amino acids that can increase the production of neurotransmitters. Each neurotransmitter has its own building blocks.
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The synthesis of a neuropeptide is very much like the synthesis of any secretory protein made by the cell. First, within the cell nucleus, gene transcription takes place, during which a specific peptide-coding sequence of DNA is used as a template to construct a corresponding strand of messenger RNA.
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Neurotransmitters are responsible for sending the messages from one neuron to the next. While they exist throughout the body, they are most prevalent in the brain. Understanding brain function and responses to various psychopharmacological agents depends on a basic understanding of these internal chemicals.
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Scientists have found that gut bacteria produce neurotransmitters such as serotonin, dopamine and GABA, all of which play a key role in mood (many antidepressants increase levels of these same compounds).
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Key types of neurotransmitters Experts have identified more than 100 neurotransmitters to date. Neurotransmitters have different types of action: Excitatory neurotransmitters encourage a target cell to take action. Inhibitory neurotransmitters decrease the chances of the target cell taking action.
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Nonclassical transmitters are produced in a regulated manner, in contrast to classical neurotransmitters that are produced in advance and stored within secretory vesicles which are released upon stimulation of the cell.