Hypertension treatment with diuretics, ACE inhibitors, and calcium channels blockers were more prevalent in tinnitus patients, suggesting that an eventual ototoxicity of these drugs may be involved in tinnitus pathophysiology, a hypothesis that should be evaluated in further studies.
Do ACE inhibitors cause hearing loss?
ACE inhibitors are medications used to lower blood pressure and may cause ringing in the ears. These drugs typically end in “-il” (common examples are lisinopril, enalapril, and ramipril). Angiotensin receptor blockers (ARBs) are similar medications that appear to carry the same very rare tinnitus risk.
Which medication group is most likely to cause ototoxicity?
Of all ototoxic drugs, the aminoglycosides are the most vestibulotoxic, although they vary greatly in their differential effects on the vestibular and cochlear systems. Kanamycin, amikacin, neomycin, and dihydrostreptomycin are preferentially cochleotoxic.
Brand names of the common loop diuretics include Bumex, Edecrin, Lasix and Demadex. High blood pressure is often treated today with Hydrochlorothiazide (HCTZ), which is not a loop diuretic and does not usually cause ototoxicity.
What are five common medications that are potentially ototoxic and may cause hearing loss?
Ototoxic medicines that may cause hearing loss include aminoglycosides, macrolide antibiotics, antimalarials, platinum-based antineoplastic agents, anti-inflammatory medicines and loop diuretics (Table 1)2.
How does ototoxic drugs affect hearing?
In most cases, hearing loss occurs because the medicine damages the cochlea in the inner ear. Hearing loss caused by an ototoxic medicine tends to develop quickly. The first symptoms usually are ringing in the ears (tinnitus) and vertigo. Hearing usually returns to normal after you stop taking the medicine.
Which drug most likely to cause loss of equilibrium and auditory damage is?
Kanamycin and amikacin are close to neomycin in cochleotoxic potential and are both capable of causing profound, permanent hearing loss while sparing balance. Gentamicin and tobramycin have vestibular and cochlear toxicity, causing impairment in balance and hearing.
Is metoprolol an ototoxic?
Focusing on drugs acting on the cardiovascular system, ototoxic significant RORs emerged for bisoprolol (2.84, 1.17″6.87), nebivolol (4.40, 1.82″10.66), metoprolol (4.97, 1.59″15.54), ramipril (2.50, 1.44″4.33), irbesartan (10.44, 4.91″22.17), and doxazosin (3.73 1.54″9.03).
Which drug causes loss of equilibrium and auditory damage?
Aspirin and quinine Aspirin (acetylsalicylic acid, ASA) and quinine are well known to cause temporary ototoxicity resulting in tinnitus. They may also reduce hearing, particularly when given at high doses. Quinine products can also temporarily reduce balance ability.
Does ibuprofen cause ototoxicity?
Pain medication can be hurting your hearing. Today we have firm evidence that ibuprofen, a common pain relief medication, can increase incidents of hearing loss in people as they age. As such, you may want to avoid certain medications in an effort to protect your hearing health.
What high blood pressure meds cause tinnitus?
Blood pressure medications ” ACE inbihibitors (Lisinopril and Enalprel) have been known to cause tinnitus. Beta Blockers like Propranolol and Nebivolol (Bystolic) can rarely cause tinnitus. Propranolol is also used for anxiety disorders including performance anxiety.
Is Lasix ototoxic?
Some classes of diuretics, commonly called water pills, have ototoxic properties. These drugs include Lasix (furosemide) and Demadex (torsemide), and can cause ringing in the ears or hearing loss that usually goes away when the medication is discontinued.
Do ACE inhibitors cause tinnitus?
ACE inhibitors are medications used to lower blood pressure and may cause ringing in the ears. These drugs typically end in “-il” (common examples are lisinopril, enalapril, and ramipril). Angiotensin receptor blockers (ARBs) are similar medications that appear to carry the same very rare tinnitus risk.
Can BP meds cause hearing loss?
Diuretics medicines such as furosemide or bumetanide used to treat high blood pressure and heart failure can also cause hearing loss. The medicines are more likely to result in hearing loss if you take more than one at a time, ASHA reports.
Can diltiazem cause tinnitus?
Nervous System: Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor.
Are statins ototoxic?
Drug-associated ototoxicity is a potentially irreversible adverse event. Among the several 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) available in the United States, only atorvastatin is associated with tinnitus, but none are associated with any forms of hearing loss.
Can omeprazole cause hearing loss?
Theoretically, PPIs could inhibit H+/K+ -ATP-ase in the inner ear, leading to suppression of the endocochlear potential. Disturbance of the endocochlear potential may lead to hearing loss and/or tinnitus.
Is ototoxic hearing loss reversible?
The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. There are many well-known ototoxic drugs used in clinical situations, and they are prescribed, despite the risk of hearing disorders, for very serious health conditions.
Which findings indicate that a patient is experiencing an ototoxic effect?
“ringing in the ears” (tinnitus). This also can cause strange sounds like hissing, buzzing, humming, and roaring. major problems with balance. hearing problems, usually in both ears (called bilateral hearing loss).
What is ototoxicity and nephrotoxicity?
Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used during intensive phase of treatment of multi-drug resistant tuberculosis (MDR-TB) patients.
Are beta blockers Ototoxic?
In fact, beta blockers can be found on lists of ototoxic medications according to clinicians’ expert opinions (Cianfrone et al.
Which drug is nephrotoxic as well as Ototoxic Mcq?
It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity.
Why do loop diuretics cause ototoxicity?
The most likely mechanism responsible for the potentiation of ototoxicity by loop diuretics is damage to the tight cell junctions in the blood vessels in the stria vascularis resulting in temporary disruption of the blood-cochlear barrier which increases the permeability of the lateral wall to ototoxic drugs.
Is Lexapro ototoxic?
Paroxetine, sertraline, duloxetine, escitalopram, and vortioxetine were antidepressants with significant ototoxic adjusted RORs (2.67, 1.10″6.45; 2.99, 1.24″7.24; 3.11, 1.16″8.33; 3.15, 1.17″8.44; and 13.18, 4.18″41.58, respectively).
Are all NSAIDs ototoxic?
High doses of nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be ototoxic in animals and in human case reports,15 potentially through a reduction in cochlear blood flow. Pre-exposure to salicylates and NSAIDs may potentiate noise-induced hearing loss.